Wednesday, September 17, 2014

Mikhail Baryshnikov, Gregory Hines, Usher, and…the Cytation™ 3?


My daughter (seen above) is a dancer, and has been since the age of 3. Most evenings you can find me driving her to and from the two dance studios which she attends to take classes in multiple forms of dance, including contemporary, jazz, musical theater, tap, and ballet. Many times as I am watching her, I am amazed that one hour she can be moving as graceful as a swan, then with a quick change of shoes and a drink of water, her feet are tapping faster than a penguin in "Happy Feet", and then with a final change she is dancing so cool and smooth, even Usher would be proud. I’m also amazed at how she can make a difficult variation from "The Nutcracker" look so easy to perform; even when dancing en pointe.

This is much the same with the Cytation 3 Cell Imaging Multi-Mode Reader. In a typical day researchers can analyze the potential cytotoxic effect of a test compound through the use of a luminescent cell viability kit, assess protein-protein interactions using a TR-FRET assay, determine transfection efficiency through image-based subpopulation analyses, and monitor reactive oxygen species activation in real time using kinetic microscopy, just to name a few possibilities. The imager, combined with its data analysis package, Gen5, can also make difficult types of analysis, such as that from 3D tumor invasion assays become much easier to accomplish.


3d tumor invasion
(3D tumor invasion in response to CXCL12 chemoattractant monitored over 120 hours)

While we might not see the Cytation 3 starring in any upcoming episodes of "Dancing With the Stars", I would venture to say that the smiles appearing after seeing the images and data generated from a complicated experiment will be very similar to those I have every time I see my daughter dance.

By: BioTek Instruments, Brad Larson, Principal Scientist

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